Kalsium Sulfat sebagai Bone Graft

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Eddy Eddy


Calcium sulfate, which is also known as gypsum or Plaster of Paris has been used widely for more than a century. The use of calcium sulfate is not limited only to industry or food, but also to medicine and dentistry. Furthermore, calcium sulfate can be used as a bone graft for bone regeneration after tooth extraction or other bone loss cases. The development of calcium sulfate has attracted much attention from researchers due to its full biodegradability in bone defects, stimulatory effect on angiogenesis, minimal inflammatory responses, and low cost of production. This article reviews the use of calcium sulfate as a bone graft in medicine and dentistry as well as the advantages and the disadvantages.



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Author Biography

Eddy Eddy

Bagian Bahan Kedokteran Gigi, Fakultas Kedokteran Gigi,Universitas Trisakti


Dimitriou, R., Jones, E., McGonagle, D. et al. Bone regeneration: current concepts and future directions. BMC Med. 2011;9:66. DOI:10.1186/1741-7015-9-66

Marsell R, Einhorn TA. (2011). The biology of fracture healing. Injury. Vol.42, No.6, pp. 551-555. DOI:10.1016/j.injury.2011.03.031

Polo-Corrales L, Latorre-Esteves M, Ramirez-Vick JE. Scaffold design for bone regeneration. J Nanosci Nanotechnol. 2014;14(1):15-56. DOI:10.1166/jnn.2014.9127

Kumar P, Vinitha B, Fathima G. Bone grafts in dentistry. J Pharm Bioallied Sci. 2013;5(1):125-127. DOI:10.4103/0975-7406.113312

Singh NB, Middendorf B. Calcium sulphate hemihydrate hydration leading to gypsum crystallization. Prog Cryst Growth Ch. 2007;53:57-77. DOI:10.1016/jpcrysgrow.2007.01.002

Jia YH, Sun PF. (2015). Comparison of Clinical Outcome of Autograft and Allograft Reconstruction for Anterior Cruciate Ligament Tears. Chin Med (Engl). 2015;128(23):3163-3166. DOI:10.4103/0366-6999.170265

Fishman JA, Scobie L, Takeuchi Y. Xenotransplantation-associated infectious risk: a WHO consultation. Xenotransplantation. 2012;19(2):72-81. DOI:10.1111/j.1399-3089.2012.00693.x

Eddy, Tsuchiya A, Tsuru K, Ishikawa K. Fabrication of self-setting β-TCP granular cement using β-TCP granules and sodium hydrogen sulfate solution. J Biomater Appl. 2018;33(5):630-636. DOI:10.1177/0885328218808015

Putri, TS, Rianti D, Rachmadi P, Yuliati A. Effect of glutaraldehyde on the characteristics of chitosan–gelatin–β-tricalcium phosphate composite scaffolds. Mater. Lett. 2021;304. DOI:10.1016/j.matlet.2021.130672

Leiblein M, et,al. Size matters: Effect of granule size of the bone graft substitute (Herafill®) on bone healing using Masquelet’s induced membrane in a critical size defect model in the rat’s femur. J Biomed Mater Res B Appl Biomater. 2019;108(4):1469-1482. DOI:10.1002/jbm.b.34495

Park JC, Kim YH, Choi HS, et al. (2017). The rate and stability of mandibular block bone graft in recent 5 years. Maxillofac Plast Reconstr Surg. 2017;39(1):21. DOI:10.1186/s40902-017-0118-0

Stubbs D et al. In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model. Biomaterials. 2004;25(20):5037-5044

Beuerlein MJ, McKee MD. Calcium sulfates: what is the evidence? J Orthop Trauma. 2010;24(1):45-61. DOI:10.1097/BOT.0b013e3181cec48e

Dvorak-Ewell MM et al. Osteoblast extracellular Ca2+-sensing receptor regulates bone development, mineralization and turnover. J Bone Miner Res. 2011;26(12):2935–2947. DOI:10.1002/jbmr.520

Strocchi R et al. Bone regeneration with calcium sulfate: evidence for increased angiogenesis in rabbits. J Oral Implantol. 2002;28(6):273-278. DOI:10.1563/1548-1336(2002)028<0273:BRWCSE>2.3.CO;2

Slater N et al. Backscattered electron imaging and elemental microanalysis of retrieved bone tissue following maxillary sinus floor augmentation with calcium sulphate. Clin Oral Implants Res. 2008;19(8): 814–822. DOI:10.1111/j.1600-0501.2008.01550.x

Gao C et al. Fabrication of calcium sulfate/PLLA composite for bone repair. J Biomed Mater Res A. 2005;73(2):244-53. DOI:10.1002/jbm.a.30283

Zhao Z et al. (2020). The effect of calcium sulfate/calcium phosphate composite for the treatment of chronic osteomyelitis compared with calcium sulfate. Ann Palliat Med. 2020;9(4):1821-1833.

Tsuchiya A, Sato M, Ichiro T, Ishikawa K. (2018). Fabrication of apatite-coated gypsum granules and histological evaluation using rabbits. Ceram Int. 2018;44(16): 20330-20336. DOI:10.1016/j.ceramint.2018.08.021

Peltier LF. (1961). The use of plaster of Paris to fill defects in bone. Clin Orthop. 1961;21:1-31.

Tan WL, Wong TL, Wong MC, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res. 2012;23(5);1-21. DOI:10.1111/j.1600-0501.2011.02375.x

Bagoff R et al. Socket preservation and sinus augmentation using a medical grade calcium sulfate hemihydrate and mineralized irradiated cancellous bone allograft composite. J Oral Implantol. 2013;39(3): 363-71. DOI:10.1563/AAID-JOI-D-10-00178.

Pecora D, De Leonardis D, Ibrahim N, Bovi M, Cornelini R. The use of calcium sulphate in the surgical treatment of a `through and through` periradicular lesion. Int Endod J. 2001;34(3):189-98. DOI:10.1046/j.1365-2591.2001.00369.x

Laino L, Troiano G, Giannatempo G, et al. Sinus lift augmentation by using calcium sulphate. A retrospective 12 months radiographic evaluation over 25 treated Italian patients. Open Dent J. 2015;9:414-419. DOI:10.2174/1874210601509010414

Kim JH, Oh JH, Han I, Kim HS, Chung SW. Grafting using injectable calcium sulfate in bone tumor surgery: comparison with demineralized bone matrix-based grafting. Clin Orthop Surg. 2011;3(3):191-201. DOI:10.4055/cios.2011.3.3.191